Table 2 Relative hazards of recurrence or death in patients with pulmonary metastases secondary to colo-rectal cancer (univariate analysis in cox proportional hazards model, time since operation for lung metastasis)
| Â | Recurrence | Death | ||
|---|---|---|---|---|
Gender(F versus M) | 2.1 (0.8 - 5.1) | 0.12 | 1.7 (0.6 - 4.4) | 0.30 |
Age(per 10 years) | 0.84 (0.52 - 1.34) | 0.46 | 1.05 (0.61 - 1.79) | 0.86 |
Primary Tumor T stage | Â | 0.34 | Â | 0.60 |
   1-2 | 1.0 |  | 1.0 |  |
   3 | 4.0 (0.5 - 30.5) |  | 2.8 (0.4 - 21.7) |  |
   4 | 2.6 (0.3 - 23.3) |  | 3.0 (0.3 - 27.1) |  |
Tumor 3-4 (vs. 1-2) | 3.6 (0.5 - 26.8) | 0.22 | 2.8 (0.4 - 21.6) | 0.32 |
Primary Tumor N stage | Â | 0.23 | Â | 0.42 |
   0 | 1.0 |  | 1.0 |  |
   1 | 2.3 (0.8 - 6.9) |  | 1.7 (0.5 - 5.6) |  |
   2 | 2.7 (0.8 - 9.3) |  | 2.2 (0.6- 7.8) |  |
Node 1-2 (versus 0) | 2.4 (0.9 - 6.7) | 0.09 | 1.9 (0.7 - 5.5) | 0.22 |
Primary tumors M stage | 3.2 (1.1 - 8.9) | 0.03 | 1.4 (0.5 - 4.5) | 0.53 |
M1 (versus M0) | Â | Â | Â | Â |
Stage 3-4 (versus 1-2) | 2.4 (0.9 - 6.7) | 0.09 | 1.8 (0.6 - 5.1) | 0.28 |
Liver metastasis | 3.1 (1.2 - 7.8) | 0.01 | 2.3 (0.8 - 6.2) | 0.10 |
Time primary to lung(per year) | 0.9 (0.6 - 1.2) | 0.51 | 1.0 (0.8 - 1.4) | 0.87 |
Time primary to first metastasis(per year) | 0.71 (0.49 - 1.02) | 0.06 | 0.9 (0.6 - 1.2) | 0.45 |
Multiple versus single lung metastasis | 1.2 (0.5 - 3.3) | 0.67 | 1.2 (0.9 - 1.7) | 0.17 |
Size lung metastasis >20 mm | 1.8 (0.7 - 4.8) | 0.21 | 1.2 (0.4 - 3.2) | 0.76 |
Neo-adjuvant treatment for lung metastasis | 2.8 (0.6 - 13.0) | 0.20 | 3.4 (0.9 - 12.4) | 0.06 |
Adjuvant treatment for lung metastasis | 0.5 (0.1 - 3.9) | 0.52 | 1.1 (0.3 - 4.9) | 0.89 |
Lung operation other than wedge(versus wedge) | 2.3 (0.9 - 5.9) | 0.06 | 1.8 (0.7 - 5.0) | 0.23 |