Table 2 Gender specific adiponectin and leptin levels and resistin, MCP-1, active PAI-1, TNF-α, IL-1α, IL-6, IL-8, and IL-10 levels of septic patients (SP), morbidly obese (MO) and controls (BD).
Parameters (normal values) | SP (n = 33) (Median; range) | MO (n = 37) (Median; range) | BD (n = 60) (Median; range) | Change SP vs. BD | Change MO vs. BD |
|---|---|---|---|---|---|
Adiponectin (μg/ml) | 10.3 (2.9 - 47.6) | 9.4 (3.8 - 57.8) | 14.7 (5.7 - 54.0) | ↓ p = < 0.01 | ↓ p = < 0.01 |
Adiponectin male (μg/ml) | 9.5 (2.9 - 32.6) | 8.3 (3.8 - 12.3) | 11.8 (5.7 - 30.7) | ↓ p = 0.04 | ↓ p = < 0.01 |
Adiponectin female (μg/ml) | 13.2 (5.3 - 47.6) | 12.4 (5.3 - 57.8) | 22.5 (9.8 - 54.0) | ↓ p = 0.02 | ↓ p = < 0.01 |
Leptin (ng/ml) | 6.3 (0.3 - 80.7) | 45.0 (1.7 - 97.5) | 10.8 (0.3 - 58.5) | no significant change | ↑ p = < 0.01 |
Leptin male (ng/ml) (< 7 ng/ml) | 6.3 (0.3 - 24.7) | 34.2 (1.7 - 90.9) | 4.6 (0.3 - 19.1) | no significant change | ↑ p = < 0.01 |
Leptin female (ng/ml) (< 18 ng/ml) | 8.2 (0.9 - 80.7) | 47.3 (16.1 - 97.5) | 15.8 (0.7 - 58.5) | no significant change | ↑ p = < 0.01 |
Resistin (ng/ml) | 78.1 (13.4 - 52.3) | 9.9 (3.7 - 83.6) | 10.8 (5.2 - 24.9) | ↑ p = < 0.01 | no significant change |
MCP-1 (pg/ml) | 381.5 (72.3 - 887.3) | 108 (39.6 - 293) | 43.9 (12.1 - 150) | ↑ p = < 0.01 | ↑ p = < 0.01 |
Active PAI-1 (ng/ml) | 35.9 (11.5 - 160.3) | 57.5 (3.7 - 176.7) | 6.0 (2.4 - 31.3) | ↑ p = < 0.01 | ↑ p = < 0.01 |
TNF-α (pg/ml) | 13.1 (2.4 - 65.5) | 4.0 (2.4 - 26.8) | 3.9 (1.2 - 10.9) | ↑ p = < 0.01 | no significant change |
IL-1α (pg/ml) | 68.6 (9.2 - 203.3) | 59.4 (9.2 - 210.0) | 11.0 (9.2 - 168) | ↑ p = 0.04 | ↑ p = 0.01 |
IL-6 (pg/ml) | 163.6 (14.4 - 10000) | 2.9 (0.9 - 64.2) | 0.7 (0.4 - 568.6) | ↑ p = < 0.01 | ↑ p = < 0.01 |
IL-8 (pg/ml) | 59.4 (4.6 - 1335.6) | 3.7 (0.3 - 38.8) | 9.8 (0.9 - 126.7) | ↑ p = < 0.01 | ↓ p = < 0.01 |
IL-10 (pg/ml) | 26.7 (3.9 - 276.7) | 2.5 (2.4 - 8.6) | 1.2 (0.9 - 1038) | ↑ p = < 0.01 | ↑ p = 0.01 |