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Effect of beta blockers on the incidence of atrial fibrillation in elderly patients after abdominal surgery
BMC Surgery volume 13, Article number: A32 (2013)
Aim of the study
To determine whether treatment with Beta Blockers during abdominal surgery would reduce the incidence of post-operative Atrial Fibrillation (AF).
Post operative AF is a common problem in patients following surgery. The incidence of such arrhythmia has been reported to range from 20–35% and increase to the age and to presence of comorbidities [1–3]. Also, AF is related to many complications and it is still debated what is the best interventions, especially in the elderly . Sympathetic nervous system activation is strictly related to surgery stress  and treatment with Beta Blockers may reduce this overactivation that predispose to AF occurence [6–10].
A pilot study was conducted with 30 elderly patients (age > 65 years) who underwent abdominal surgery (right emicolectomy, sigmoidectomy and anterior rectal resection). They were randomized to control (ctr) (n = 14) and Beta Blockers (beta) (n = 16) groups. Before surgery all elderly patients have been taking Beta Blockers (for hypertension or heart failure). During and after surgery only the beta group received the medication. Both groups were well matched and had the same demographic and clinical characteristics.
After surgery 5 patients of ctr group and in 1 patients of beta group developed AF (p < 0.001). All patients with AF occurrence were >75 years old.
Beta Blockers could not be stopped during abdominal surgery in elderly patients (with hypertension or heart failure) because significantly reduce the incidence of post-operative AF. Moreover, the link between the older age and AF occurrence is confirmed also in this population.
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Pagano, G., Leosco, D., Ferrara, N. et al. Effect of beta blockers on the incidence of atrial fibrillation in elderly patients after abdominal surgery. BMC Surg 13, A32 (2013). https://0-doi-org.brum.beds.ac.uk/10.1186/1471-2482-13-S1-A32
- Heart Failure
- Atrial Fibrillation
- Elderly Patient
- Pilot Study