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Figure 7 | BMC Surgery

Figure 7

From: Ca2+-dependent nitric oxide release in the injured endothelium of excised rat aorta: a promising mechanism applying in vascular prosthetic devices in aging patients

Figure 7

Caveolar impairment impairs both the Ca2+ response to ATP and the accompanying NO production in rat aortic endothelium. A, pre-treatment with 10 mM MβCD to disrupt caveolae significantly hinders both the magnitude and the plateau of the Ca2+ response to ATP (300 μM). Both phases depend on store-dependent Ca2+ inflow when ATP is administered at this dose. The traces are the mean±SE of 220 (PSS, black trace) and 186 cells (MβCD, red trace), respectively, from no less than three different animals. B, MβCD (10 mM) suppresses ATP-induced NO synthesis. The traces are the mean±SE, respectively, of 150 (PSS, closed circles) and 4 (MβCD, open circles) cells from no less than three different animals.

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