Table 2 Quality assessment of included randomized controlled trials

CURE [3, 19]

Yes

Yes (central randomization)

Yes

Yes

Yes (0.1 %: 13/12,562 overall; 0 % of CABG)

PLATO [5, 17]

Yes

Yes (central randomization)

Yes

Yes

Yes (0.03 %: 5/18,624 overall)

TRITON-TIMI 38 [4, 11]

Yes

Yes (central randomization)

Yes

Yes

Yes (0.1 %: 14/13,608 overall)

CREDO [18, 20]

Yes

Yes

Yes

Yes

Yes (0 %)

CRYSSA [22]

No

Yes

Yes

Yes

Yes (0.3 %: 1/300)

CASCADE [21]

Yes

Yes

Yes

Yes

Yes (0 %)

Gao 2010 [15]

No

Unclear

Yes

Yes

Yes (3.7 %: 9/249)

Sun 2010 [16]

Yes

Yes

Yes

Yes

Yes (1.0 %: 1/100)

Gasparovic 2014 [23]

No

Yes

Yes

Yes

Yes (2.2 %: 5/224)