Long-term prognosis after resection of cryptogenic hepatocellular carcinoma

Table 2 Results of univariate and multivariate analysis of predictors for the recurrence of CR-HCC, B-HCC, and C-HCC

Variables	Category	P(uni)	P(multi)	Multi hazard ratio
CR-HCC
Number of tumors	Single/multiple	0.004
Intraoperative RBC transfusion	Yes/no	0.060
Degree of primary differentiation	well, moderate/poorly	0.078
Tumor size	<50/≧50 mm	0.029	0.014	3.0 (1.3–7.0)
Cancer spread	Yes/no	0.005	0.001	4.1 (1.7–9.6)
Platelet count	<10 × 10⁴/≧10 × 10⁴ /ml	0.058	0.004	4.4 (1.6–12.1)
B-HCC
Degree of differentiation of the main tumor	well, moderate/poorly	0.140
Tumor size	<50/≧50 mm	0.018
Platelet count	<10 × 10⁴/≧10 × 10⁴ /ml	0.070	0.038	1.7 (1.0–2.7)
C-HCC
Number of tumors	Single/multiple	0.004	0.016	1.5 (1.1–2.2)
Degree of differentiation of the main tumor	well, moderate/poorly	0.015	0.067	1.3 (0.98–1.9)
Tumor size	<50/≧50 mm	0.067
Cancer spread	Yes/no	0.001	0.001	1.6 (1.2–2.2)
Surgical margin	Positive/Negative	0.116
LC	Yes/no	0.004	0.058	1.3 (0.99–1.7)
ICGR15	<15/≧15 %	0.003	0.014	1.5 (1.1–2.0)
Platelet count	<10 × 10⁴/≧10 × 10⁴ /ml	0.014
AFP	<100/≧100 AU/l	<0.001	0.038	1.4 (1.0–1.8)

CR-HCC cryptogenic hepatocellular carcinoma, B-HCC hepatitis virus B-related hepatocellular carcinoma, C-HCC hepatitis virus C-related hepatocellular carcinoma, AFP alpha-fetoprotein, DCP des-r-carboxyprothrombin, ICGR15 indocyanine green retention rate at 15 min, LC Liver cirrhosis