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Fig. 1 | BMC Surgery

Fig. 1

From: Atorvastatin does not protect against ischemia-reperfusion damage in cholestatic rat livers

Fig. 1

Pathophysiological mechanisms in hepatocytes and sinusoidal endothelial cells (SEC) as a result of ischemia/reperfusion and cholestasis in the context of the pharmacodynamics of atorvastatin (ATV). The sites where ATV has been demonstrated to intervene are indicated and serve as a basis for this study. Abbreviations: ROS, reactive oxygen species; DAMPs, damage-associated molecular patterns; TLR-4, Toll-like receptor-4; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; TXA2, thromboxane A2; ET-1, endothelin-1; NO, nitric oxide; eNOS, endothelial nitric oxide synthase; SEC, sinusoidal endothelial cell

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