Table 3 Comparison of ganglion cell detection between hematoxylin and eosin (HE) staining and S100 immunohistochemistry in the diagnosis of Hirschsprung disease according to age at full-thickness rectal biopsy
From: The utility of the hematoxylin and eosin staining in patients with suspected Hirschsprung disease
Age at full-thickness rectal biopsy | HE staining | S100 immunohistochemistry | |
|---|---|---|---|
Ganglion cells absent (N, %) | Ganglion cells present (N, %) | ||
Neonate | Ganglion cells absent (N, %) | 5 (62.5) | 1 (12.5) |
Ganglion cells present (N, %) | 0 | 2 (25) | |
≤1 year old | Ganglion cells absent (N, %) | 3 (33) | 1 (11) |
Ganglion cells present (N, %) | 2 (23) | 3 (33) | |
>1 year old | Ganglion cells absent (N, %) | 4 (66) | 1 (17) |
Ganglion cells present (N, %) | 0 | 1 (17) | |