Surgery-associated acquired hemophilia A: a report of 2 cases and review of literature

Khan, Umar Zeb; Yang, Xiangwu; Masroor, Matiullah; Aziz, Abdul; Yi, Hui; Liu, Hai

doi:10.1186/s12893-020-00872-y

BMC Surgery

Table 2 Reported cases of surgery-associated acquired hemophilia A (SAHA)

From: Surgery-associated acquired hemophilia A: a report of 2 cases and review of literature

Case	Age/gender	Surgical operation	Time from surgery to bleeding	FVIII Inhibitor titer	Hemostatic treatment	Anti-inhibitor treatment	Time to disappearance of inhibitor	Outcome	Ref
1	27/F	Episiotomy	6 days	19BU	FIX	Cyclo	–	Death	[14]
2	77/M	Retinal surgery	4 days	NS	FVIII, Cryo	Steroids,Cyclo	NS	Remission	[15]
3	25/F	Cholecystectomy	1 day	4UB	APCC	IVIG	NS	Reop, Remission	[16]
4	47/M	Bowel resection	4 days	3.3UB	FVIII,Cryop	Steroids, IVIG, PLME	40 days	2Reop, Remission	[17]
5	70/F	Cholecystectomy	1 day	5BU	FVIII	Steroids, 6-MP	2 months	Reop, Death	[17]
6	74/F	Coronary artery bypass	7 days	16BU	FVIII, APCC	Steroids, Cyclo	–	6.5BU 8 years later	[17]
7	73/M	Prostate surgery	2 days	42BU	–	IVIG	NS	Death	[18]
8	75/M	Hernia repair	4 days	10.4BU	rFVIIa	Steroids, Aza, cyclo	7 months	Reop, Remission	[19]
9	79/F	Cataract surgery	0 day	61BU	FVIII	Steroids, IVIG	NS	Reop, Remission	[20]
10	53/M	Lumbar surgery	8 days	NS	rFVIIa	Steroids	8 weeks	Remission	[21]
11	62/M	Liver transplant	2 days	6BU	FVIII, PLME	Steroids	2 months	Reop, Remission	[22]
12	57/M	Brain surgery	7 days	2BU	FVIII	Steroids, cyclosporin	8 weeks	Reop, Remission	[23]
13	82/M	Eyelid surgery	0 day	NS	rFVIIa	Steroids	NS	Reop, Remission	[24]
14	59/M	Lumbar surgery	0 day	8BU	FVIII, Cryop,	Cyclo, Steroids	15 days	Remission	[25]
15	57/F	Pancreaticojejunostomy	2 days	117BU	FVIII, rFVIIa	Steroids	100 days	Reop, Death	[26]
16	71/M	Pancreaticojejunostomy	5 days	8BU	FVIII	Steroids, rituximab	124 days	Remission	[27]
17	86/F	Mohs surgery	0 day	NS	FVIII	Steroids	NS	Reop, Remission	[28]
18	63/M	PEG	6 days	10 BU	–	Steroids	NS	Remission	[29]
19	65/M	Lysis of adhesion	1 day	5.5BU	rFVIIa	Steroids	NS	Reop,Remission	[30]
20	79/M	Pancreaticodudenectomy	3 days	18.7BU	APCC	Steroids, Cyclo	67 days	Remission	[31]
21	55/M	Cardiac surgery	0 day	66 BU	FVIII, rFVIIa,	Steroids, Cyclo	3 months	Reop, Remission	[32]
22	62/F	choledochal cyst resection	6 days	2BU	rFVIIa, APCC	IVIG, rituximab, cyclosporin	18 days	Reop, Remission	[33]
23	84/M	Distal gastrectomy	2 days	7BU	rFVIIa,	Steroids	230 days	Reop, Remission	[34]

NS not stated, BU Bethesda units, rFVIIa recombinant activated factor VII, IVIG intravenous immunoglobulin, APCCs activated prothrombin complex concentrates, PEG percutaneous endoscopic gastrostomy, Cyclo cyclophosphamide, Cryop Cryoprecipitate, PLME plasma exchange, 6-MP 6-mercaptopurine, Aza azathioprine

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ISSN: 1471-2482

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