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Table 6 Univariate analysis of risk factors for postoperative morbidity and severe morbidity in patients received lobectomy

From: Analysis of risk factors for postoperative complications in non-small cell lung cancer: comparison with the Japanese National Clinical Database risk calculator

Variables

 

Morbidity

P value

Severe morbidity

P value

  

Absent, n (%)

Present, n (%)

 

Absent, n (%)

Present, n (%)

 

Sex

Man

209 (68.9)

94 (31.1)

0.52

262 (86.5)

41 (13.5)

0.01

 

Woman

122 (71.8)

48 (28.2)

 

159 (93.5)

11 (6.5)

 

Age

 ≥ 75

77 (72.6)

29 (27.4)

0.49

94 (88.7)

12 (11.3)

0.90

 

 < 75

254 (69.2)

113 (30.8)

 

327 (89.1)

40 (10.9)

 

Comorbidity

       

Malignant disease

Absent

288 (69.4)

127 (30.6)

0.46

369 (88.9)

46 (11.1)

0.86

 

Present

43 (74.1)

15 (25.9)

 

52 (89.7)

6 (10.3)

 

Angina pectoris

Absent

311 (70.5)

130 (29.5)

0.33

392 (88.9)

49 (11.1)

0.76

 

Present

20 (62.5)

12 (37.5)

 

29 (90.6)

3 (9.4)

 

Cerebral infarction

Absent

318 (70.2)

135 (29.8)

0.61

402 (88.7)

51 (11.3)

0.38

 

Present

13 (65.0)

7 (35.0)

 

19 (95.0)

1 (5.0)

 

Interstitial lung disease

Absent

325 (69.7)

141 (30.3)

0.36

415 (89.1)

51 (10.9)

0.77

 

Present

6 (85.7)

1 (14.3)

 

6 (85.7)

1 (14.3)

 

Chronic renal failure

Absent

329 (70.5)

138 (29.5)

0.04

416 (89.1)

51 (10.9)

0.65

 

Present

2 (33.3)

4 (66.7)

 

5 (83.3)

1 (16.7)

 

Diabetes mellitus

Absent

284 (70.7)

118 (29.3)

0.45

358 (89.1)

44 (10.1)

0.93

 

Present

47 (66.2)

24 (33.8)

 

63 (88.7)

8 (11.3)

 

COPD

Absent

315 (70.9)

129 (29.1)

0.07

398 (89.6)

46 (10.4)

0.08

 

Present

16 (55.2)

13 (44.8)

 

23 (79.3)

6 (20.7)

 

Asthma

Absent

326 (71.0)

133 (29.0)

 < 0.01

410 (89.3)

49 (10.7)

0.20

 

Present

5 (35.7)

9 (64.3)

 

11 (78.6)

3 (21.3)

 

Arrhythmia

Absent

321 (70.2)

136 (29.8)

0.50

407 (89.61

50 (10.9)

0.84

 

Present

10 (62.5)

6 (37.5)

 

14 (87.5)

2 (12.5)

 

Autoimmune disease

Absent

323 (69.9)

139 (30.1)

0.84

412 (89.2)

50 (10.8)

0.44

 

Present

8 (72.7)

3 (27.3)

 

9 (81.8)

2 (18.2)

 

Hypertension

Absent

279 (69.7)

121 (30.3)

0.79

354 (88.5)

46 (11.5)

0.40

 

Present

52 (71.2)

21 (28.8)

 

67 (91.8)

6 (8.2)

 

Smoking status

Brinkman index < 600

180 (76.3)

56 (23.7)

 < 0.01

213 (90.3)

23 (9.7)

0.38

 

Brinkman index ≥ 600

151 (63.7)

86 (36.3)

 

208 (87.8)

29 (12.2)

 

BMI

 < 22.93

165 (70.8)

68 (29.2)

0.69

217 (93.2)

16 (6.8)

 < 0.01

 

 ≥ 22.93

166 (69.2)

74 (30.8)

 

204 (85.0)

36 (15.0)

 

CEA

 ≤ 5

240 (72.7)

90 (27.3)

0.04

297 (90.0)

33 (10.0)

0.29

 

 > 5

91 (63.6)

52 (36.4)

 

124 (86.7)

19 (13.3)

 

PNI

 ≥ 49.68

190 (73.9)

67 (26.1)

0.04

234 (91.1)

23 (8.9)

0.12

 

 < 49.68

141 (65.3)

75 (34.7)

 

187 (86.6)

29 (13.4)

 

NLR

 ≤ 1.56

97 (78.2)

27 (21.8)

0.01

111 (89.5)

13 (10.5)

0.83

 

 > 1.56

234 (67.1)

115 (32.9)

 

310 (88.8)

39 (11.2)

 

%VC

 ≥ 80

325 (70.4)

137 (29.6)

0.25

414 (89.6)

48 (10.4)

 < 0.01

 

 < 80

6 (54.6)

5 (45.4)

 

7 (63.6)

4 (36.4)

 

FEV1%

 ≥ 70

231 (74.3)

80 (25.7)

 < 0.01

281 (90.4)

30 (9.6)

0.19

 

 < 70

100 (61.7)

62 (38.3)

 

140 (86.4)

22 (13.6)

 

Histological type

Non-Squamous cell carcinoma

279 (71.2)

113 (28.8)

0.21

354 (90.3)

38 (9.7)

0.04

 

Squamous cell carcinoma

52 (64.2)

29 (35.8)

 

67 (82.7)

14 (17.3)

 

Operative approach

VATS or RATS

295 (69.4)

130 (30.6)

0.42

380 (89.4)

45 (10.6)

0.40

 

Open thoracotomy

36 (75.0)

12 (25.0)

 

41 (85.4)

7 (14.6)

 

Operative procedure

RML or LLL

90 (81.1)

21 (18.9)

 < 0.01

105 (94.6)

6 (5.4)

0.03

 

RUL or RLL or LUL

241 (66.6)

121 (33.4)

 

316 (87.3)

46 (12.7)

 
  1. COPD chronic obstructive pulmonary disease, CEA carcinoembryonic antigen, PNI prognostic nutritional index, NLR neutrophil-to-lymphocyte ratio, VC vital capacity, FEV1% forced expiratory volume % in one second, VATS video-assisted thoracic surgery, RATS robotic-assisted thoracic surgery, RML right middle lobectomy, LLL left lower lobectomy, RUL right upper lobectomy, RLL right lower lobectomy, LUL left upper lobectomy