From: A systematic review on the use of topical hemostats in trauma and emergency surgery
Year | Design | Comments | GoR-LoE | |
---|---|---|---|---|
Annegg U et al. [31]. | 2007 | Ranzomized, single-center | The use of TachoSil® after pulmonary resection resulted in reduction of air leak with significant shortening of time of tube removal and of hospital length of stay | 1C |
Belda-Sanchis et al. [32] | 2010 | Cochrane review | Surgical sealants have some beneficial effects in reducing postoperative air leaks, but their systematic use cannot be recommended at the moment | 1A |
Briceno et al. [24] | 2010 | Prospective controlled | The fibrin sealant after major liver resection was effective for decreasing drainage volume; postoperative blood transfusion requirements; moderate to severe postoperative complications and mean hospital stay | 1C |
Chalmers et al. [3] | 2010 | Prospective randomized | Tranexamic acid-free fibrin sealant is safe, and significantly shortened the time to haemostasis in vascular procedures using PTFE | 1B |
Chapman et al. [4] | 2007 | Phase 3, randomized, double-blind | Recombinant thrombin has comparable efficacy, a similar safety profile, and is considerably less immunogenic than bovine thrombin when used for surgical hemostasis | 1C |
Cheng et al. [29] | 2016 | Cochrane review | Considering the lack of effect on prevention of POPF, high costs, and the potential harms for endocrine pancreatic function, fibrin sealants should not be recommended routinely for people undergoing pancreatic surgery | 1A |
Colombo et al. [14] | 2014 | Systematic review | TachoSil® has a role as a supportive measure to improve hemostasis and promote tissue sealing when standard techniques are insufficient | 1B |
Cormio et al. [33] | 2012 | Prospective randomized | TachoSil sealed tubeless PCNL does not reduce pain and analgesic requirements, but it significantly reduces urinary leakage and postoperative hospital stay | 2A |
De Boer et al. [19] | 2012 | Systematic review | Fibrin sealants can be effective as an adjunct to achieve hemostasis during liver resections. However, considering lack of evidence on the efficacy of fibrin sealants in reducing postoperative resection surface-related complications, routine use of fibrin sealants in liver surgery cannot be recommended. | 1B |
Dhillon et al. [1] | 2011 | Systematic review | Liquid fibrin sealants are effective as adjunctive measure to improve hemostasis | 1B |
Echave et al. [2] | 2014 | Systematic review | Floseal® showed improvement over other hemostatics agents in achieving hemostatis and reducing blood loss | 1B |
Erdogan et al. [16] | 2007 | Systematic review | There is no clear proof of the biliostatic efficacy of topical hemostatic agents used after liver resection on the resection surface | 1B |
Esposito et al. [23]. | 2016 | Systematic review | Fibrin sealants provide a higher rate of intraoperative watertight closure of dura suture line and they may be effective in preventing cerebrospinal fluid leaks with an acceptable safety profile | 1B |
Figueras et al. [17] | 2007 | Prospective randomized | Application of fibrin sealants in the raw surface after hepatectomy does not seem justified | 1C |
Filosso et al. [30] | 2013 | Prospective randomized | TachoSil® was superior to standard stapling and suturing aerostatic techniques in reducing postoperative air leaks in patients undergoing redo thoracic surgery. | 1B |
Fisher et al. [5] | 2011 | Randomized, multicenter | Tranexamic acid- and aprotinin-free fibrin sealant is safe and effective for achieving hemostasis in soft tissue during elective retroperitoneal or intra-abdominal surgery. | 1B |
Fisher et al. [10] | 2013 | Prospective randomized | Fibrin pad is superior to absorbable hemostat in soft-tissue bleeding control and is safe and effective for rapidly and reliably achieving hemostasis | 1B |
Genyk et al. [12] | 2016 | Multicenter randomized open-lable | The FSP (TachoSil®) was safe and superior to ORCG (Surgicel Original) for achieving hemostasis in patients undergoing hepatic resection | 1B |
Green et al. [22] | 2015 | Multicenter, prospective randomized | Fibrin sealant is effective as an adjunct to dural sutures to provide watertight closure of the dura mater in neurosurgery | 1C |
Jankowitz et al. [21] | 2009 | Retrospective | The use of fibrin glue for dural repair did not significantly decrease the incidence of a persistent cerebrospinal fluid leak | 2A |
Kobayashi et al. [18] | 2016 | Multicenter randomized | Fibrin sealant with polyglicolic acid compared with collagen fleece did not reduce biliary leakage and hemorrhage | 1C |
Koea et al. [11] | 2015 | Randomized controlled | The FP is safe and superior to SoC for controlling challenging severe soft-tissue bleeding encountered during intra-abdominal and thoracic surgical procedures | 1C |
Maisano et al. [13] | 2009 | Randomized controlled | TachoSil® was significantly superior to standard haemostatic fleece material in obtaining effective and fast intra-operative haemostasis in cardiovascular surgical procedures. TachoSil was safe and well tolerated. | 1B |
Montorsi et al. [27] | 2012 | Multicenter randomized controlled | TachoSil® had no significant effect on the rate of POPF, although there was a significant reduction of amylase level in drainage fluid on postoperative day 1. | 1B |
Marangos et al. [26] | 2011 | Retrospective | The application of the TachoSil® patch did not affect either occurrence of POPF or duration of postoperative hospital stay. Routine use of TachoSil® patch to prevent pancreatic fistulas does not provide clinically significant benefit. | 1C |
Perussi Biscola et al. [20] | 2017 | Systematic review | The new heterologous fibrin sealant from snake venom represents a consistent alternative to biological sealants, since they may avoid transmission of infectious diseases | 1C |
Pommergaard et al. [26] | 2013 | Systematic review | Liquid fibrin adhesive should be beneficial to prevent leak of ileal anastomoses in gastric and bariatric surgery | 1C |
Saha et al. [9] | 2012 | Prospective randomized | Fibrin sealant is safe and its efficacy is superior to manual compression for hemostasis in patients with vascular ePTFE graft | 1C |
Schwartz et al. [6] | 2004 | Prospective randomized controlled | Crosseal fibrin sealant significantly reduces the time of hemostasis following liver resection in comparison with the standard topical hemostatic agents | 1C |
Simo et al. [15] | 2012 | Systematic review | Application of TachoSil® in hepatobiliary and pancreatic surgery has proven effectiveness in hemostasis and as tissue sealant | 1C |
Spotniz et al. [7] | 2012 | Systematic review | Fibrin sealants have multiple new uses that should result in further improvement in patient care | 1C |
Taylor et al.[8] | 2003 | Randomized prospective multicenter | Fibrin sealants are more effective than thrombin-soaked gelatin sponge for achieving hemostasis of needle or suture hole bleeding from PTFE femoral artery grafts. | 1B |
Vakalopoulos et al. [25] | 2012 | Systematic review | Fibrin sealant seem not be necessary as external coating of colonic anastomoses to prevent leakage | 1C |