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Table 5 Tumor characteristics and surgical outcomes in Low and High PNI groups

From: Onodera’s prognostic nutritional index is a strong prognostic indicator for patients with hepatocellular carcinoma after initial hepatectomy, especially patients with preserved liver function

 

Low PNI

(PNI < 37: n = 17)

High PNI

(PNI ≥ 37: n = 172)

p value

PNI median

33.6 (26.0–36.9)

45.9 (37.3–60.0)

 

Tumor size (cm)

4.7 (1.1–15.0)

4.0 (0.5–24.0)

n.s

Multiple tumor

7 (41%)

42 (24%)

n.s

AFP (ng/ml)

62 (2–60,105)

11 (1–253,875)

0.05

DCP (mAU/ml)

1094 (14–85,330)

92 (1–286,400)

n.s

BCLC stage

  

n.s

 0

0 (0%)

17 (10%)

 

 A

13 (76%)

108 (63%)

 

 B

3 (18%)

35 (20%)

 

 C

1 (6%)

12 (7%)

 

Within Milan criteria

9 (53%)

98 (57%)

n.s

Tumor differentiation

   

 Well

2 (13%)

40 (28%)

n.s

 Moderately

10 (62%)

80 (56%)

 

 Poorly

4 (25%)

22 (16%)

 

Vascular invasion

   

 vp ( +)

9 (56%)

55 (38%)

n.s

 vv ( +)

1 (6%)

11 (8%)

n.s

Operation time (minutes)

336 (159–526)

335 (127–983)

n.s

Blood loss (ml)

1711 (520–10,382)

1080 (0–36,000)

n.s

 ≥ 2 sectionectomy

3 (18%)

54 (31%)

n.s

Complications (C-D ≥ IIIa)

5 (29%)

33 (20%)

n.s

Mortality

2 (12%)

8 (5%)

n.s

PT-INR on POD5

1.20 (0.98–1.71)

1.12 (0.92–1.52)

0.03

Total bilirubin on POD5 (mg/dl)

1.5 (0.5–11.2)

0.9 (0.3–8.3)

0.012

  1. Differences were considered significant at p < 0.05, shown as italic values
  2. AFP alpha fetoprotein, DCP des-γ-carboxyprothrombin, BCLC stage Barcelona clinic liver cancer stage, C–D Clavien–Dindo, POD postoperative day, PT-INR prothrombin time-international normalized ratio, vp ( +) portal vein invasion including microvascular invasion, vv ( +) hepatic vein invasion including microvascular invasion
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BMC Surgery

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