Variables | Number (n;%) | DFS HR (95% CI) | P-value | OS HR (95% CI) | P-value |
---|---|---|---|---|---|
Age |  | 1.018 (0.646–1.603) | 0.939 | 1.522 (1.040–2.227) | 0.027 |
 ≥ 70 years | 89 (47.34) |  |  |  |  |
 < 70 years | 99 (52.66) |  |  |  |  |
Sex |  | 0.831 (0.503–1.373) | 0.464 | 1.031 (0.654–1.627) | 0.894 |
Male | 142(75.53) | Â | Â | Â | Â |
Female | 46 (24.47) | Â | Â | Â | Â |
BMI |  | 0.744 (0.475–1.165) | 0.190 | 0.693 (0.473–1.013) | 0.054 |
 ≥ 25.97 kg/m2 | 92 (48.93) |  |  |  |  |
 < 25.97 kg/m2 | 96 (51.07) |  |  |  |  |
ASA Score |  | 0.755 (0.480–1.187) | 0.217 | 1.271 (0.846–1.909) | 0.242 |
I/II | 64 (34.04) | Â | Â | Â | Â |
III/IV | 124(65.96) | Â | Â | Â | Â |
Hepatitis A |  | 0.401 (0.146–1.100) | 0.064 | 0.965 (0.517–1.801) | 0.909 |
Yes | 20 (10.64) | Â | Â | Â | Â |
No | 168 (89.36) | Â | Â | Â | Â |
Hepatitis B |  | 1.101 (0.661–1.833) | 0.709 | 0.720 (0.442–1.170) | 0.178 |
Yes | 42 (22.34) | Â | Â | Â | Â |
No | 146 (77.66) | Â | Â | Â | Â |
Hepatitis C |  | 0.723 (0.426–1.226) | 0.222 | 0.829 (0.536–1.281) | 0.392 |
Yes | 56 (29.79) | Â | Â | Â | Â |
No | 132 (70.21) | Â | Â | Â | Â |
Child–Pugh Score |  | 0.991 (0.628–1.563) | 0.964 | 1.419 (0.966–2.084) | 0.018 |
No cirrhosis | 22 (11.70) | Â | Â | Â | Â |
A | 143 (76.06) | Â | Â | Â | Â |
B | 22 (11.70) | Â | Â | Â | Â |
C | 1 (0.53) | Â | Â | Â | Â |
Co-morbidity | |||||
 Cardiac |  | 0.666 (0.392–1.130) | 0.126 | 1.310 (0.885–1.939) | 0.170 |
 Yes | 65 (34.57) |  |  |  |  |
 No | 123 (65.43) |  |  |  |  |
 Pulmonary |  | 1.039 (0.612–1.763) | 0.888 | 1.301 (0.853–1.984) | 0.214 |
 Yes | 43 (22.87) |  |  |  |  |
 No | 145 (77.13) |  |  |  |  |
 Renal insufficiency |  | 0.740 (0.356–1.541) | 0.415 | 1.159 (0.681–1.973) | 0.580 |
 Yes | 27 (14.36) |  |  |  |  |
 No | 161 (85.64) |  |  |  |  |
 Diabetes mellitus |  | 1.402 (0.887–2.215) | 0.142 | 1.491 (1.010–2.200) | 0.040 |
 Yes | 64 (34.04) |  |  |  |  |
 No | 124 (65.6) |  |  |  |  |
 Chronic alcohol abuse |  | 1.736 (1.052–2.866) | 0.027 | 1.121 (0.716–1.754) | 0.614 |
 Yes | 37 (19.68) |  |  |  |  |
 No | 151 (80.32) |  |  |  |  |
 MELD Score |  | 1.323 (0.842–2.078) | 0.218 | 1.360 (0.926–1.999) | 0.111 |
  ≥ 8 | 107 (56.91) |  |  |  |  |
  < 8 | 81 (43.09) |  |  |  |  |
 Tumor Diameter |  | 1.697 (1.081–2.666) | 0.019 | 1.715 (1.164–2.526) | 0.005 |
  ≥ 45 mm | 97 (51.59) |  |  |  |  |
  < 45 mm | 91 (48.41) |  |  |  |  |
 Single lesion | 111 (59.04) | 1.259 (0.806–1.968) | 0.306 | 1.284 (0.880–1.873) | 0.188 |
 Multiple lesions | 77 (40.96 |  |  |  |  |
 Unilobular lesion(s) | 134 (71.28) | 1.455 (0.898–2.355) | 0.121 | 1.292 (0.863–1.935) | 0.206 |
 Bilobular lesions | 54 (28.72) |  |  |  |  |
 T-Stage |  | 1.129 (0.642–1.985) | 0.669 | 1.583 (1.029–2.436) | 0.033 |
 I/II | 149 (79.26) |  |  |  |  |
 III/IV | 39 (20.74) |  |  |  |  |
 M-Stage |  | 6.672(1.554–28.642) | 0.003 | 5.106 (2.043–12.760) |  < 0.0001 |
 M0 | 183 (97.34) |  |  |  |  |
 M1 | 5 (2.66) |  |  |  |  |
 Grade |  | 1.284 (0.677–2.438) | 0.438 | 1.773 (1.085–2.896) | 0.019 |
 I/II | 157 (83.51) |  |  |  |  |
 III/IV | 31 (16.49) |  |  |  |  |
Resection margin | |||||
 R < 0.1 cm | 33 (17.55) | 1.216 (0.701–2.107) | 0.482 | 1.174 (0.729–1.892) | 0.504 |
 R > 0.1 cm | 155 (82.45) |  |  |  |  |
 R < 0.5 cm | 72 (38.30) | 1.105 (0.698–1.751) | 0.667 | 0.906 (0.617–1.330) | 0.610 |
 R > 0.5 cm | 116 (61.70) |  |  |  |  |
 L-Stage |  | 1.708 (0.623–4.683) | 0.288 | 2.833 (1.370–5.859) | 0.003 |
 L0 | 178 (94.68) |  |  |  |  |
 L1 | 10 (5.32) |  |  |  |  |
 V-Stage |  | 0.811 (0.406–1.622) | 0.594 | 2.249 (1.539–3.287) |  < 0.0001 |
 V0 | 156 (82.98) |  |  |  |  |
 V1 (micro) | 29 (15.43) |  |  |  |  |
 V2 (macro) | 3 (1.60) |  |  |  |  |
 UICC-Stage |  | 1.267 (0.962–1.669) | 0.006 | 1.512 (1.227–1.863) |  < 0.0001 |
 I | 111 (59.04) |  |  |  |  |
 II | 43 (22.87) |  |  |  |  |
 III | 28 (14.89) |  |  |  |  |
 IV | 6 (3.19) |  |  |  |  |
 ISLT/PVE |  | 1.393 (0.561–3.454) | 0.468 | 1.839 (0.984–3.434) | 0.049 |
 Yes | 15 (7.98) |  |  |  |  |
 No | 173 (92.02) |  |  |  |  |
 Segments ≥ 3 |  | 1.171 (0.745–1.842) | 0.489 | 1.783 (1.221–2.606) | 0.002 |
 Yes | 83 (44.15) |  |  |  |  |
 No | 105 (55.85) |  |  |  |  |
 Biliary reconstruction |  | 1.162 (0.364–3.707) | 0.797 | 2.417 (1.323–4.416) | 0.003 |
 Yes | 14 (7.45) |  |  |  |  |
 No | 174 (92.55) |  |  |  |  |
 T-Drainage |  | 1.456 (0.874–2.425) | 0.143 | 0.902 (0.560–1.453) | 0.667 |
 Yes | 38 (20.21) |  |  |  |  |
 No | 150 (79.79) |  |  |  |  |
 Operative time |  | 0.710 (0.451–1.118) | 0.134 | 1.356 (0.927–1.984) | 0.111 |
  ≥ 307 min | 94 (50.00) |  |  |  |  |
  < 307 min | 94 (50.00) |  |  |  |  |
 Intraoperative transfusion |  | 0.708 (0.437–1.147) | 0.155 | 1.248 (0.852–1.828) | 0.248 |
 Yes | 74 (39.36) |  |  |  |  |
 No | 114 (60.64) |  |  |  |  |
 CD ≥ 3a |  | 1.351 (0.845–2.160) | 0.202 | 2.272 (1.555–3.319) |  < 0.0001 |
 Yes | 73 (38.83) |  |  |  |  |
 No | 115 (61.17) |  |  |  |  |
 Bile leak |  | 1.168 (0.600–2.276) | 0.644 | 0.966 (0.529–1.761) | 0.908 |
 Yes | 20 (10.64) |  |  |  |  |
 No | 168 (89.36) |  |  |  |  |
 Intra-abdominal abscess |  | 4.152 (2.036–8.467) |  < 0.0001 | 1.755 (0.982–3.137) | 0.051 |
 Yes | 14 (7.45) |  |  |  |  |
 No | 174 (92.55) |  |  |  |  |
 Cholangitis |  | 0.829 (0.203–3.386) | 0.792 | 2.885 (1.541–5.402) |  < 0.0001 |
 Yes | 13 (6.91) |  |  |  |  |
 No | 175 (93.09) |  |  |  |  |
 Sepsis |  | 1.218 (0.161–9.221) | 0.847 | 19.225 (9.947–37.159) |  < 0.0001 |
 Yes | 19 (10.11) |  |  |  |  |
 No | 169 (89.89) |  |  |  |  |
 Wound infection |  | 0.948 (0.486–1.846) | 0.873 | 1.332 (0.802–2.210) | 0.260 |
 Yes | 24 (12.77) |  |  |  |  |
 No | 164 (87.23) |  |  |  |  |
 ISGLS B/C |  | 1.287 (0.755–2.193) | 0.347 | 2.992 (2.026–4.420) |  < 0.0001 |
 Yes | 58 (30.85) |  |  |  |  |
 No | 130 (69.15) |  |  |  |  |