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Comparative study on the selection of drainage methods in posterior lumbar interbody fusion
BMC Surgery volume 23, Article number: 207 (2023)
Abstract
Objective
To compare and analyze the clinical effects of bilateral natural pressure drainage and negative pressure drainage after posterior lumbar interbody fusion (PLIF) to provide a reference for selecting drainage methods after lumbar surgery.
Methods
A retrospective cohort study, 281 patients who underwent single-segment PLIF in our hospital from January 2017 to December 2020 and met the inclusion and exclusion criteria were included in the study, including 132 males and 149 females, aged 22–85 years, with an average of (53.62 ± 11.23) years. According to different postoperative incision drainage methods determined by the random number table method before surgery, they were divided into the natural pressure drainage group and negative pressure drainage group, both of which were bilateral drainage. The general observation indexes and perioperative-related indexes were recorded and analyzed.
Results
There were 143 cases in the natural pressure drainage group and 138 cases in the negative pressure drainage group. There was no significant difference in age, gender, body mass index, disease type, blood pressure on the day of surgery, preoperative albumin, hemoglobin, platelet, prothrombin time, and intraoperative bleeding between the two groups (P > 0.05). The albumin on the first postoperative day in the natural pressure drainage group was higher than that in the negative pressure drainage group [(33.24 ± 3.52) vs. (32.17 ± 5.03), P < 0.05]; The hemoglobin on the first postoperative day in the natural pressure drainage group was higher than that in the negative pressure drainage group [(126.01 ± 15.03) vs. (115.19 ± 16.25), P < 0.01]; The drainage volume on the first postoperative day in the natural pressure drainage group was lower than that in the negative pressure drainage group [(93.25 ± 63.58) ml vs. (119.46 ± 54.48) ml, P < 0.01]; The total postoperative drainage volume in the natural pressure drainage group was lower than that in the negative pressure drainage group [(355.60 ± 189.69) ml vs. (434.37 ± 149.12) ml, P < 0.01]; The indwelling time of drainage tube in the natural pressure drainage group was lower than that in the negative pressure drainage group [(3.29 ± 1.17) d vs. (3.45 ± 0.97) d, P < 0.05]. There was no significant difference in platelet count on the first postoperative day, postoperative hospital stays, and complications (incision infection and hematoma) between the two groups (P > 0.05).
Conclusion
Bilateral natural pressure drainage and negative pressure drainage can achieve good drainage effects after PLIF, but patients with natural pressure drainage have less loss of albumin and hemoglobin, less drainage volume, and shorter drainage tube indwelling time, which is worthy of clinical application.
Background
Drainage tube placement in the spinal decompression area is routine to ensure smooth postoperative drainage and reduce hematoma compression and infection [1,2,3,4]. With the continuous advancement of minimally invasive concepts and hemostasis technology, there is no unified standard for the number, method, indwelling time, and removal criteria of drainage tubes placed in the operation area. Clinicians usually place drainage tubes according to their experience, including unilateral drainage, bilateral drainage, natural pressure drainage, and negative pressure drainage. There are also options not to put a drainage tube. How to choose a more reasonable, effective drainage method with fewer complications is worth thinking about. Posterior lumbar interbody fusion (PLIF) is a classic operation of posterior lumbar decompression, fixation, and fusion, it is still the operation method commonly used by spine surgeons [5], and there is no unified standard for the placement of drainage tubes. Therefore, this paper compares and analyzes the clinical effects of bilateral natural pressure drainage and negative pressure drainage after single-segment PLIF to provide a reference for the drainage tube placement in the surgical area after PLIF.
Materials and methods
Inclusion and exclusion criteria
Inclusion criteria: (1) Confirmed by X-ray, CT, MRI, and other imaging examinations as degenerative and isthmic spondylolisthesis, lumbar stenosis, lumbar disc herniation instability, single-segment intervertebral instability, and degenerative scoliosis; (2) The clinical symptoms and signs of the patients consistent with the clinical manifestations of the corresponding diseases, and the course of the disease lasts for more than 6 months with a decrease in quality of life; (3) Progressive worsening or no significant relief of symptoms after more than 6 months of strict conservative treatment; (4) Implemented single-segment PLIF; (5) Age range from 18 to 85 years old, regardless of gender; (6) Obtained complete follow-up.
Exclusion criteria: (1) Previous history of lumbar spine surgery; (2) Combined lumbar infection, tumor, and deformity; (3) Combined diabetes and severe cardiovascular disease; (4) Preoperative evaluation showed abnormal coagulation function or received blood transfusion treatment during or after surgery; (5) Intraoperative dural rupture or postoperative cerebrospinal fluid leak.
General information
A retrospective cohort study, 281 patients who underwent single-segment PLIF in our hospital from January 2017 to December 2020 and met the inclusion and exclusion criteria were included in the study, including 132 males and 149 females, aged 22–85 years, with an average of (53.62 ± 11.23) years. Before surgery, patients were assigned to the natural pressure drainage group and negative pressure drainage group using the random table method according to their case IDs. All patients were informed of the drainage method to be used before surgery and written consent was obtained from all patients. According to the different drainage methods, they were divided into 143 cases in the natural pressure drainage group and 138 cases in the negative pressure drainage group.
Clinical characteristics and evaluation indicators
After hospitalization, patients’ height and weight were measured, body mass index (BMI) was calculated, serum albumin, hemoglobin, platelets, and prothrombin time were measured 24 h before and after surgery. Patients’ blood pressure was measured on the day of surgery, intraoperative blood loss, drainage volume within 24 h after surgery, drainage tube indwelling time, total drainage volume, and postoperative hospitalization stays were recorded. After surgery, closely observe the patients’ vital signs, lower limb nerve function, and incision dressing.
Diagnostic criteria for deep incision infection: (1) Finding purulent fluid through deep incision drainage; (2) Body temperature exceeding 38 ℃, local tenderness or spontaneous pain, or spontaneous dehiscence of the deep incisions; (3) Abscess or other evidence of deep incision infection was confirmed through incision examination, secondary surgery, histopathological diagnosis, and imaging examination; (4) The surgeon made a diagnosis of deep incision infection, or obtained positive results by performing debridement and pus microbiological culture.
Diagnostic criteria for symptomatic hematoma: The possibility of symptomatic hematoma is suspected when the following conditions occur after surgery. (1) Nerve root injury, unilateral or bilateral sciatica; (2) Cauda equina injury, delayed paralysis below the injury level, with sensory and motor dysfunction, loss of sphincter function, decreased muscle tension, disappearance of tendon reflexes, no pathological pyramidal signs; (3) Progressive aggravation of wound and surrounding pain, accompanied by massive wound bleeding or swelling of the wound area. Subsequently, blood routine examination and coagulation function tests were repeated to determine the existence of thrombocytopenia and coagulation dysfunction, and the final diagnosis was confirmed through MRI or surgery.
Surgical methods
The same medical team operated on all patients. In the prone position, a median longitudinal incision, 4-6Â cm long, exposes the spinous process, lamina, facet joint, and the root of the transverse process layer by layer. Four pedicle screws were placed using the Magerl method. The lower 2/3 of the upper lamina of the diseased segment and the upper 1/3 of the lower lamina were removed, the hypertrophic ligamentum flavum was gradually removed, and the lateral recess was enlarged. Decompression until bilateral nerve roots are released without compression. The intervertebral disc was scraped clean and filled with autologous bone, an intervertebral cage was placed, and compression fixation between the vertebral bodies was finally performed. Irrigated the incision using normal saline 1500 ml, and posterolateral autogenous and allogenic bone grafts were performed. Hemostasis was carefully achieved until there was no active bleeding.
All patients received bilateral drainage. Incise the skin with a scalpel at 1–2 cm below the incision, place two drainage tubes under the muscle layer, and fix them with 7# suture. The drainage tubes all retained three lateral holes and were placed in the space between the back of the vertebral lamina and the front of the erector spinae muscle. The outlet of the drainage tube is connected with an ordinary drainage bag (natural pressure drainage group) or a negative pressure drainage ball (negative pressure drainage group). Close the fascia, subcutaneous tissue, and skin layer by layer, and wrap them with sterile dressings.
Application method of natural pressure drainage and negative pressure drainage device
The diameter of the drainage tube is 4.7 mm. The drainage tubes of the natural pressure drainage group and the negative pressure drainage group are respectively connected with a disposable ordinary drainage bag and a disposable negative pressure drainage ball. They are all transparent and marked with scales, which are convenient for observing the drainage fluid’s properties, color, and flow. All drainage devices were placed on both sides below the level of the surgical incision to avoid backflow. The negative pressure ball always maintains a negative pressure of 10–20 kPa. The removal standard of drainage tubes is drainage volume ≤ 50ml/24 h (Fig. 1).
Postoperative use of antibiotics, anticoagulants, and other drugs
Cefazolin sodium was used to prevent infection within 24Â h after the operation, and low molecular weight heparin (4100Â U, QD, 3-5Â d) was subcutaneously injected 12Â h after operation to prevent deep vein thrombosis. Treatments such as nerve nutrition and fluid replacement were given.
Statistical methods
Continuous variables are expressed as (mean ± standard) deviation. Chi-squared test was used to compare categorical variables, the Shapiro-Wilk test was used to detect the normality of continuous variables, and two independent samples t-test or Mann-Whitney U test were used to compare normal or partial normal continuous variables respectively. Statistical analysis was performed using IBM SPSS Statistics 26 software, P < 0.05 was considered statistically significant.
Results
There was no significant difference between the two groups in age, gender, height, weight, BMI, disease type, blood pressure on the day of surgery, preoperative albumin, hemoglobin, platelet, prothrombin time, and intraoperative bleeding (P > 0.05). In addition, no patients with degenerative scoliosis were included in this study because there were no patients admitted for hospitalization for degenerative scoliosis during the study period. See Table 1.
The albumin on the first postoperative day in the natural pressure drainage group was higher than that in the negative pressure drainage group [(33.24 ± 3.52) vs. (32.17 ± 5.03), P < 0.05]; The hemoglobin on the first postoperative day in the natural pressure drainage group was higher than that in the negative pressure drainage group [(126.01 ± 15.03) vs. (115.19 ± 16.25), P < 0.01]; The drainage volume on the first postoperative day in the natural pressure drainage group was lower than that in the negative pressure drainage group [(93.25 ± 63.58) ml vs. (119.46 ± 54.48) ml, P < 0.01]; The total drainage volume in the natural pressure drainage group was lower than that in the negative pressure drainage group [(355.60 ± 189.69) ml vs. (434.37 ± 149.12) ml, P < 0.01]; The indwelling time of drainage tube in the natural pressure drainage group was lower than that in the negative pressure drainage group [(3.29 ± 1.17) d vs. (3.45 ± 0.97) d, P < 0.05]. There was no significant difference in platelet count on the first postoperative day, postoperative hospital stays, and complications between the two groups (P > 0.05). The postoperative parameters of the two groups are shown in Table 2.
Discussion
PLIF is a classic surgical procedure for posterior lumbar decompression, fixation, and fusion. Due to the extensive stripping of paravertebral muscles, resection of laminae, articular processes, ligamentum flavum, and other tissues, involving the handle of venous plexus in the spinal canal, the nerve roots and dural sac are directly exposed to the incision cavity, which may cause hematoma and poor drainage, resulting in serious complications such as wound infection and nerve compression [6]. Therefore, it is essential to place drainage tubes after surgery. Meanwhile, in recent years, there has also been a view of not indwelling drainage, arguing that the incidence of symptomatic hematomas and infections is not affected by whether or not they are drained [7,8,9]. Related studies suggest that drainage does not have a significant impact on reducing the incidence of postoperative complications or improving clinical efficacy [10], in contrast to the fact that indwelling drainage tubes requires more surgical procedures and trauma, increases blood loss and transfusion [11, 12], and can cause local discomfort, coupled with compliance problems and psychological fear, often leading to an extension of postoperative bed rest [13]. However, in clinical practice, most surgeons still routinely place drainage tubes after surgery to smoothly drain blood and exudate from surgical wounds [14], prevent the occurrence of epidural hematoma and infection [15, 16]. There is no unified standard on whether to place negative pressure drainage or natural pressure drainage in the surgical area after PLIF, as well as the specification, quantity, and placement position of drainage tubes. Ahn et al. [17] found no statistical difference between the clinical effects of drainage tubes with a diameter of 1.6 mm and 2.8 mm, so the diameter of the drainage tube had little effect on the postoperative drainage effect. According to the study by Guo et al. [18], the clinical effect of placing double drainage tubes after lumbar surgery is better than placing single drainage tube, and some studies have found that placing double drainage tubes after PLIF can prevent drainage failure caused by drainage tube blockage and other causes [19]. Therefore, it is recommended to place double drainage tubes after lumbar open surgery. Merter et al. [20] found that there was no significant difference in the cross-sectional area of the spinal cord at 24 h after surgery when the drainage tube was placed in the surgical incision, 1 cm outside the incision and 5 cm outside the incision, but the spinal cord was significantly compressed when the drainage tube was placed more than 5 cm outside the incision. Therefore, it was considered that the distance between the position of the drainage tube leading out of the skin and the surgical incision should not exceed 5 cm. In this study, natural pressure drainage and negative pressure drainage were placed 1–2 cm outside and below the bilateral incision, the diameter of the drainage tube was 4.7 mm. The clinical application effect was good, and there were no severe complications such as poor drainage and nerve compression by hematoma in the incision.
Albumin and hemoglobin are essential components in human plasma. Invisible blood loss after PLIF often leads to patients with a low nutritional status (albumin < 35 g/L), causing anemia or aggravation of anemia. Clinically, it is usually corrected by diet, the supplement of amino acid preparation and iron, and intravenous infusion of serum albumin and plasma. The results of this study show that under the same drainage tube removal standard, natural pressure drainage can reduce the loss of the above two proteins, which has the advantages of improving perioperative safety, improving postoperative symptoms such as fatigue and hypotension, promoting postoperative functional recovery, shortening hospital stay, reducing patient costs, improving patient satisfaction and saving albumin and blood resources. The drainage tube placement can affect postoperative recovery [21,22,23]. Patients who use natural pressure drainage can remove the drainage tube earlier and reduce postoperative pain caused by the stimulation of the drainage tube. It is in line with the concept of enhanced recovery after surgery (ERAS) [24], which is conducive to early out-of-bed activities and early intervention of rehabilitation training to improve the early function of patients and restore the self-care ability of daily life as soon as possible. In addition, the postoperative loss of albumin and hemoglobin and long-term drainage are the risk factors for complications such as surgical site infection [25,26,27,28], hemorrhagic anemia [7, 29, 30], and delirium [31, 32] after PLIF. Compared with negative pressure drainage, natural pressure drainage can reduce the level of the above risk factors and is theoretically safer.
However, this study also has some limitations. For example, none of the participants included in this study had postoperative complications such as incision infection and symptomatic hematoma, which may be related to the fact that the operation segment was a single segment and the operation time was short. The study excluded patients with diabetes, severe cardiovascular and cerebrovascular diseases, and cases with intraoperative dural rupture or postoperative cerebrospinal fluid leakage, thus not reaching the severity of infection caused by bacterial colonization [33]. Considering that the purpose of this study is to exclude bias factors, it is only relevant to the clinical efficacy of different drainage methods after PLIF. Therefore, this study needs further improvement with a multi-center, large sample, and prospective study.
To sum up, using bilateral natural pressure drainage after PLIF can reduce postoperative drainage volume, reduce postoperative albumin and hemoglobin loss, and shorten the indwelling time of the drainage tube, which can promote early ambulation of patients and facilitate early recovery. This is a safe and effective drainage method, which is more worthy of clinical application.
Availability of data and materials
The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Abbreviations
- PLIF:
-
Posterior lumbar interbody fusion
- BMI:
-
Body mass index
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Funding
Funding for this study came from the following projects: National Natural Science Foundation of China (No. 81860395); Key Research and Development Program of Ningxia (No. 2022BEG03099); National First-class Construction Discipline Clinical Medicine Funding Project of Ningxia Medical University (No. NXYLXK2017A05).
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Chaoran Wang: analyzed and interpreted the data and was a major contributor to writing the manuscript. Xuewei Wang: collected and analyzed the data. Zongqiang Yang and Jiandang Shi: contributed to the interpretation of the results. Ningkui Niu: provided technical guidance and reviewed the manuscript. All authors assisted in shaping the research, analysis, and manuscript, and provided critical feedback. All authors have read and approved the final manuscript.
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All included participants provided written informed consent to participate in the study. All research methods used in this study were established according to the ethical guidelines of the Helsinki Declaration and relevant regulations. All experimental protocols were approved by the Ethics Committee (full name: Medical Research Ethics Review Committee of General Hospital of Ningxia Medical University).
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Wang, C., Wang, X., Yang, Z. et al. Comparative study on the selection of drainage methods in posterior lumbar interbody fusion. BMC Surg 23, 207 (2023). https://0-doi-org.brum.beds.ac.uk/10.1186/s12893-023-02106-3
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DOI: https://0-doi-org.brum.beds.ac.uk/10.1186/s12893-023-02106-3