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Prediction of the risk of severe small bowel obstruction and effects of Houpu Paiqi mixture in patients undergoing surgery for small bowel obstruction

BMC Surgery volume 24, Article number: 63 (2024) Cite this article

Abstract

Aim

Small bowel obstruction is a common condition that requires emergency surgery. Slow recovery of bowel function after surgery or the occurrence of one or more complications can exacerbate the disease and result in severe small bowel obstruction (SSBO), significantly impacting recovery. It is characterized by a failure to regain enteral nutrition promptly, requiring long-term intensive care. Therefore, it is necessary to identify factors that predict SSBO, to allow early intervention for patients likely to develop this condition.

Methods

Of the 260 patients who underwent emergency or elective surgery for small bowel obstruction between January 2018 and December 2022, 45 developed SSBO. The least absolute shrinkage and selection operator regression model was applied to optimize factor selection and multivariable logistic regression analysis was used to construct a predictive model. The performance and clinical utility of the nomogram were determined and internal validation was conducted. In addition, the effects of the Houpu Paiqi mixture on postoperative recovery were analyzed by comparing the clinical data of 28 patients who were treated with the mixture and 61patients who did not receive it.

Results

The predictors included in the prediction nomogram were age, peritonitis, intestinal resection and anastomosis, complications, operation time, Acute Physiology and Chronic Health Evaluation II score, white blood cell count, and procalcitonin level. The model had an area under the receiver operating characteristic curve of 0.948 (95% confidence interval: 0.814–0.956). Decision curve analysis demonstrated that the SSBO risk nomogram had a good net clinical benefit. In addition, treatment with the Houpu Paiqi mixture reduced postoperative exhaust time, postoperative defecation time, time to first postoperative liquid feed, and length of stay in hospital.

Conclusions

We developed a nomogram that can assist clinicians in identifying patients at greater risk of SSBO, which may aid in early diagnosis and intervention. Additionally, we found that the Houpu Paiqi mixture promoted postoperative recovery.

Peer Review reports

Introduction

Small bowel obstruction is a common condition that requires urgent surgical treatment [1, 2]. Despite advancements in surgical techniques [3,4,5], efficacy is limited by various factors, including a high postoperative complication rate and slow intestinal function recovery. In certain instances, small bowel obstruction can progress to severe small bowel obstruction (SSBO), which refers to a type of small bowel obstruction that is challenging to recover from in terms of postoperative intestinal function. It is characterized by a failure to regain enteral nutrition promptly and is often complicated by one or more additional issues such as pulmonary infections, severe hypoproteinemia, septic shock, and even death, requiring long-term intensive care. As well as the impact on patient health, SSBO prolongs hospital stays, increases costs, and reduces patient confidence and compliance [6]. Identifying the critical factors affecting postoperative recovery in patients with intestinal obstruction, particularly those who are critically ill, may allow early intervention, thus improving outcomes. However, few studies have been conducted on the identification and postoperative recovery of patients with SSBO.

Several factors influence the postoperative recovery of patients with small bowel obstruction, one of most crucial being the speed of postoperative intestinal function recovery. Prolonged intestinal obstruction leads to intestinal wall edema and local inflammation, making recovery after surgery more challenging and aggravating obstructive symptoms such as abdominal pain and distension. In addition, persistent local inflammation increases the likelihood of systemic infections. Traditional Chinese medicine has long been recognized for its ability to aid in the recovery of intestinal function [7], with Houpu Paiqi mixture being widely utilized and resulting in positive outcomes. Previous studies have demonstrated that the key constituents of Houpu Paiqi mixture possess anti-inflammatory properties, reduce oxidative stress, enhance intestinal peristalsis, and minimize postoperative adhesion formation [8,9,10,11].

This study aimed to identify potential risk factors associated with SSBO, establishing an independent prediction model for this complication. This would provide clinicians with a reliable tool for identifying patients at risk of developing SSBO after surgery. We also evaluated the clinical effectiveness of Houpu Paiqi mixture in the postoperative treatment of patients with small bowel obstruction.

Methods and materials

Study design and patients

This retrospective observational study collected and reviewed clinical data from 372 patients with small bowel obstruction who were admitted to Shaanxi Provincial People’s Hospital between January 2018 and December 2022; 28 of these patients were treated with Houpu Paiqi mixture after surgery. The exclusion criteria were as follows: (1) did not undergo surgery or mechanical strangulation obstruction; (2) gastrointestinal or abdominal tumors; (3) inflammatory bowel disease or pregnancy; (4) poor general health, including unconsciousness or severe cardiopulmonary insufficiency, which would affect the observation indicators; and (5) incomplete clinical data. Finally, 260 patients were included in this study. (Fig. 1). A small amount of liquid diet is initially provided post-flatus and defecation, before gradually transitioning to a full liquid diet and eventually a normal diet. The study was approved by Ethics Committee of Shaanxi Provincial People’s Hospital and Informed consent was obtained from all patients.

Fig. 1
figure 1

Flowchart of exclusion criteria for patient inclusion

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Data collection

Information on baseline demographic characteristics, including age and sex, were obtained from patients’ electronic medical records downloaded from the hospital information system. Clinical parameters such as body mass index (BMI), attending physician, presence of peritonitis, presence of chronic diseases (hypertension and diabetes), history of abdominal surgery, type of surgery, duration of surgery, intraoperative blood loss, postoperative complications, imaging data, laboratory indicators, and Acute Physiology and Chronic Health Evaluation (APACHE) II [12, 13] and Nutritional Risk Screening 2002 [14, 15] scores were also analyzed. Laboratory indicators included baseline and postoperative white blood cell (WBC) counts, red blood cell counts, hemoglobin levels, albumin levels, creatinine levels, procalcitonin levels, and blood gas analysis. Imaging was performed within 24 h of admission or postoperatively [16], and findings included multiple air and fluid levels on standing plain abdominal radiography, severe obstruction on abdominal computed tomography (CT), adhesion formation on abdominal CT, small intestinal fecal sign on abdominal CT, and abdominal fluid accumulation on abdominal CT. All patients underwent 64-slice spiral CT [17]. Many patients are unable to complete a CT examination after surgery. Therefore, it is necessary to refer to the admission CT scan. Adhesive bands were defined as connections between the small intestine and the anterior abdominal wall or between segments of the small intestine. Severe obstruction was defined as the presence of continuous bowel thickening accompanied by clear signs of filling and collapse, and an obstruction with a minimum diameter at least three times smaller than its maximum diameter. Small bowel fecal sign was characterized by the presence of gas and fecal-like substances in the dilated intestinal cavity at the proximal end of the small intestinal obstruction. The APACHE II score was used to assess disease severity, with a higher APACHE II score indicating a greater risk coefficient and mortality rate. The scores were assessed at admission by two experienced clinicians, and the records were reviewed for accuracy.

Clinical data from 28 patients who received postoperative treatment with the Houpu Paiqi mixture were compared with data from 61 selected patients who did not receive the Houpu Paiqi mixture treatment. Both groups were hospitalized from January 2022 to December 2022. After 2022, standardized treatment protocols for patients with small bowel obstruction were implemented within the General Surgery department. These protocols include specific indications, usage, and dosage of the Houpu Paiqi mixture. As a result, the data from after 2022 shows a certain degree of homogeneity and is considered for inclusion in the Houpu Paiqi study. Nevertheless, this did not affect the diagnosis and treatment of small bowel obstruction and SSBO.

For the patients who were treated by Houpu Paiqi mixture received an enema each day after surgery, Houpu Paiqi mixture (Ruiyang Pharmaceutical Co., Ltd, Shandong, China) 50mLwas dissolved into 250mL saline.

In addition to the baseline demographic and clinical characteristics listed above, data on the length of hospital stay, postoperative exhaust time, time to first postoperative defecation, time to first postoperative liquid feed, drainage tube withdrawal time, nasogastric tube withdrawal time, and WBC counts after treatment were collected.

Statistical analysis

Patients who developed SSBO and those who did not were compared using one-way analysis of variance, the Kruskal–Wallis test, the Mann–Whitney U test, and Pearson’s chi-squared test, as appropriate. Patients who were treated with the Houpu Paiqi mixture and those who were not were compared in the same way. Data are expressed as the mean ± standard deviation or median (quartile) for continuous variables, and frequency and percentage for categorical variables, based on the normal distribution of the data.

To identify potential predictive factors for SSBO, we employed the least absolute shrinkage and selection operator (LASSO) regression, which is an effective prediction method in high-dimensional datasets [18, 19]. The optimal value of λ was determined using ten-fold cross-validation. Subsequently, a multivariable logistic regression analysis was performed using the factors identified by the LASSO regression model. Significant predictors were selected using the backward elimination (Wald) method and used to construct a nomogram. The predictive factors were reported as a forest plot with regression coefficient (β), odds ratios (ORs), 95% confidence intervals (CIs), and P-values. Statistical significance was set at P < 0.05.

A calibration curve was plotted to evaluate the discriminatory ability of the nomogram. Decision curve analysis (DCA) was performed to assess the clinical application of the SSBO nomogram by measuring the net benefits at various threshold probabilities [20]. Internal validation was performed by bootstrapping with 500 replicates.

Results

Baseline patient characteristics and risk factors of SSBO

Of the 260 patients included in this study, 45 (17.3%) had SSBO, and 30 of these patients developed single-organ or systemic complications, with sepsis and septic shock being the most common (Fig. 2). Table 1 presents the baseline demographic information, clinical parameters, and laboratory results of patients with and without SSBO. Of the 37 variables, 8 were selected based on non-zero coefficients calculated using LASSO (logistic regression analysis Fig. 3). The selected factors were: age, peritonitis, intestinal resection and anastomosis, complications, operation time, APACHE II score, WBC count, and postoperative complications. Subsequently, these features were included in a multivariable logistic regression analysis and confirmed to be independent risk factors for SSBO (Table 2; Fig. 4).

Fig. 2
figure 2

Complications after surgery

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Table 1 Patient characteristics
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Fig. 3
figure 3

Features selection using the LASSO binary logistic regression model. A Optimal parameter (lambda) selection in the LASSO model using ten‑fold cross‑validation through the minimum criteria. Dotted vertical lines were drawn at the optimal values using the minimum criteria and 1 SE of the minimum criteria (the 1‑SE criteria). B LASSO coefficient profiles of the 37 factors. A coefficient profile plot was generated against the log(lambda) sequence. A vertical line was drawn at the value selected using ten‑fold cross‑validation, where optimal lambda resulted in 8 features with non-zero coefficients. LASSO, least absolute shrinkage and selection operator; SE, standard error

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Table 2 Logistic regression analysis of factors predictive of severe small bowel obstruction
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Fig. 4
figure 4

ORs were estimated using a logistic regression model and the backward elimination (Wald) method. The regression coefficient was denoted as β. CI, confidence interval; OR, odds ratio

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Development of the risk prediction model

Table 2 presents the results of the logistic regression analysis for age, peritonitis, intestinal resection and anastomosis, complications, operation time, APACHE II score, WBC count, and procalcitonin level. A nomogram (Fig. 5) was constructed to visualize the incorporation of these independent risk factors into a prediction model.

Fig. 5
figure 5

Nomogram for predicting SSBO risk. Each variable was assigned a score ranging from 0 to 100. The scores for each variable were added together, yielding a sum that can be located on the total points axis, predicting the probability of SSBO risk. SSBO, severe small bowel obstruction

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Performance and validation of the SSBO risk nomogram

In this cohort, the calibration curve of the SSBO risk nomogram showed good agreement (Fig. 6). The area under the receiver operating characteristic curve was 0.948 (95% CI: 0.814–0.956). Bootstrapping with 500 replicates was performed for internal validation (Fig. 7).

Fig. 6
figure 6

Nomogram calibration plot. As the solid line (performance nomogram) approached the dotted line (ideal model), the prediction accuracy of the nomogram was improved

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Fig. 7
figure 7

ROC curve generated to assess the performance of the SSBO nomogram. The area under the ROC curve for the prediction nomogram was 0.948 (95% confidence interval: 0.814–0.956). ROC, receiving operator characteristic

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Clinical application

The DCA of the SSBO nomogram is presented in Fig. 8. The decision curve demonstrates that if the threshold probability of SSBO is greater than 10%, using this SSBO predictive nomogram provides additional benefits. This predictive model therefore has a high clinical applicability.

Fig. 8
figure 8

Decision curve analysis was performed to evaluate the prediction model. The blue line represents outcomes of the prediction model and the red line represents outcomes for all patients with SSBO. The green solid horizontal line indicates the absence of SSBO in any patients. The graph illustrates the expected net benefit per patient in relation to the nomogram prediction of SSBO risk. As the model curve extends, the net benefit increases. SSBO, severe small bowel obstruction

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Effects of the Houpu Paiqi mixture

Table 3 provides the baseline demographic information, clinical parameters, and laboratory results for patients treated with the Houpu Paiqi mixture and those who did not receive this treatment. Preoperative data did not differ significantly between the two groups. However, there were statistically significant differences in postoperative measures between the two groups, including postoperative exhaust time, postoperative defecation time, time to first postoperative liquid feed, and length of stay in hospital.

Table 3 Characteristics of patients treated with and without the Houpu Paiqi mixture
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Discussion

In this study, we developed and internally validated an individualized prediction nomogram for SSBO. We identified eight easily assessed variables that could be used by medical practitioner to predict the occurrence of SSBO. These variables were: age, peritonitis, intestinal resection and anastomosis, complications, operation time, APACHE II score, WBC count, and procalcitonin levels. The nomogram demonstrated a good performance in SSBO risk prediction. The internal validation of the model revealed its strong discrimination and calibration abilities. Additionally, DCA demonstrated that this model has clinical significance in decision-making across a range of probability thresholds.

The overall function of the gut typically declines with age, potentially due to reduced exercise and changes in dietary habits [21]. Additionally, the intestinal mucosa of older individuals is more susceptible to inflammation than that of younger individuals, and this inflammatory response can exacerbate intestinal tissue damage [22,23,24]. Increased WBC counts and procalcitonin levels often indicate inflammation [25, 26]. The worsening of obstruction symptoms and emergence of signs of peritonitis prior to surgery suggests severe inflammation in the abdominal cavity; this can result in significantly impaired intestinal function and an extended postoperative recovery time. Consequently, older patients with preoperative signs of peritonitis are more likely to develop SSBO after surgery.

Operation time and the use of enterectomy and anastomosis were also independent risk factors for SSBO. The resection and anastomosis procedure not only alters the original anatomical structure of the small bowel but also disrupts intestinal continuity. Additionally, it causes traction stimulation of the normal small bowel, which slows peristalsis. Compared with adhesion-release surgery alone, enterectomy and anastomosis prolong the operation time, thus increasing the duration of anesthesia and delaying postoperative intestinal function recovery [27].

APACHE II is a non-specific critical disease scoring system commonly employed in clinical practice [13, 28]. This study identified the APACHE II score as an independent risk factor for SSBO. Postoperative complications included hypoproteinemia, sepsis, septic shock, type I respiratory failure, anastomotic fistulas, and massive ascites. These complications cause a deterioration in the general health of the patient. Physiological compensation diminishes, resulting in decreased stress tolerance, immunity, and overall ability to recover from surgical trauma, and increasing the likelihood of SSBO.

The Chinese medicine preparation Houpu Paiqi has been used in patients after adhesive intestinal obstruction surgery, achieving satisfactory results. In our study we superficially demonstrated that Houpu Paiqi mixture can promotes intestinal function recovery in clinical settings. Its main components are honokiol (Magnolia officinalis), naringin, and emodin [8,9,10]. Honokiol (HKL) is a bioactive compound extracted from several species of magnolia officinalis. HKL has a variety of biological activities, including anti-inflammatory, anti-platelet, anti-angiogenesis, anti-tumor, anti-oxidation, and anti-cardiac hypertrophy. Additionally, HKL can be considered a natural SIRT3 activator, as it can directly bind to SIRT3 and improve its enzyme activity [29,30,31,32]. Tianli Shen et al. has been demonstrated that HKL, as a candidate SIRT3 activator, may be a novel therapeutic agent for reducing ROS formation, inflammation, and NLRP3 activation, thereby improving postoperative PA formation. Naringin (NG) is a natural flavonoid (a flavanone glycoside) that has been shown to have anti-inflammatory, antioxidant, antiulcer, antiosteoporosis, and anticancer effects [33,34,35]. Shufeng Wang et al. reported that both ROS and MDA levels decreased in the adhesive tissues of the NG treatment groups, with more pronounced results in the high-dose NG group. This suggests that NG inhibited the degree of oxidative stress in adhesion tissues, and its mechanisms may be related to the ability of NG to ameliorate mitochondrial dysfunction. NG can be used as a drug to reduce the severity and incidence of adhesion, promote the early recovery of postoperative gastrointestinal function, and accelerate recovery after gastrointestinal surgery.

Emodin is a natural secondary plant product that was originally isolated from the rhizomes of Rheum palmatum. In traditional Chinese medicine, emodin is used as an anti-inflammatory agent and to improve visceral stasis and promote gut movement. Previous studies have demonstrated that emodin has various effects, including antiviral, antibacterial, antiallergenic, anti-osteoporotic, antidiabetic, anti-inflammatory, and antitumor effects, and it can reduce oxidative stress [36, 37]. Xuqi Li et al. demonstrated that emodin prevents adhesion formation in several ways, including the inhibition of inflammation, alleviation of oxidative stress, and promotion of intestinal tract movements. The main effect of emodin is to prevent abdominal adhesion formation by blocking the TGF-β signaling pathway. Their results presented in this study strongly suggest that emodin can be an effective drug for the prevention of postoperative adhesion formation.

In this study, patients treated with Houpu Paiqi mixture had shorter hospital stays than those not treated with Houpu Paiqi mixture (8.5 vs. 11 day). Furthermore, the postoperative exhaust time, the postoperative defecation time, and the time to first postoperative liquid feed were shorter in patients treated with Houpu Paiqi mixture than in those who did not receive this treatment. While there was no statistically significant difference in the WBC counts between the two groups, the WBC count in the Houpu Paiqi-treated group showed a downward trend, compared to an increased trend in patients not receiving this treatment. This suggests that the Houpu Paiqi mixture promotes intestinal function recovery, inhibits inflammation, and relieves oxidative stress. These findings are consistent with those of previous studies, which have also demonstrated a reduction in the formation of postoperative adhesions.

Limitations

The present study has several limitations. First, the retrospective nature of the study makes it difficult to eliminate bias. Additionally, the sample size was relatively small, which affected the generalizability of the findings. Second, this was a single-center study. Consequently, these data may not accurately represent the entire patient population. Third, it is important to acknowledge that the data collection was incomplete, and the risk factor analysis did not encompass all the potential factors that could predict SSBO. To address these limitations, external validation of our findings and prospective multicenter studies with large patient cohorts are required.

Conclusion

We developed a model to predict SSBO in patients undergoing surgery for small bowel obstruction, using factors that can be easily assessed in a clinical setting. In addition, previously complicated regression equations have been converted into user-friendly graphs, making it easier for clinicians to interpret and apply this model. In addition, our study superficially illustrates Houpu Paiqi mixture aids in the recovery of intestinal function postoperative. However, larger sample sizes and high-quality prospective studies are required to validate this model further.

Data availability

The data used to support the findings of this study are available from the corresponding author upon request.

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Acknowledgements

This study was completed in the Emergency surgery department and the first and second surgery department, thanks again to all staff for their help in the experiment.

Funding

This study was supported by the Shaanxi Provincial People’s Hospital Science and Technology Talent Support Plan (grant number 2021JY-15), the General Project of the Natural Science Foundation of Shaanxi Province (grant number 2022JQ-763), and the National Natural Science Foundation Youth Project (grant number 82200563).Key Research and Development Program of Shaanxi (Program No. 2020GXLH-Y-019, 2022KXJ-141), Innovation Capability Support Program of Shaanxi(Program No. 2019GHJD-14, 2021TD-40), Science and Technology Talent Support Program of Shaanxi Provincial People’s Hospital (Program No. 2021LJ-05).

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Authors and Affiliations

  1. The Second Department of General Surgery, Shaanxi Provincial People’s Hospital, 256 West Youyi Road, Xi’an, Shaanxi, 710068, China

    Ze-zheng Wang, Zhe-kui Liu, Wen-xing Ma, Yun-hua Wu & Xiang-long Duan

  2. Yan’an University, Yan’an, 716000, China

    Ze-zheng Wang & Wen-xing Ma

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  1. Ze-zheng Wang
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  2. Zhe-kui Liu
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Contributions

Ze-zheng Wang and Yun-hua Wu performed the study conception and design. Zhe-kui Liu and Wen-xing Ma contributed to acquisition of the data. Ze-zheng Wang and Yun-hua Wu analyzed and interpreted the data. Xiang-long Duan revised the manuscript. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Yun-hua Wu or Xiang-long Duan.

Ethics declarations

Ethics approval and consent to participate

The study was approved by Ethics Committee of Shaanxi Provincial People’s Hospital and Informed consent was obtained from all patients. The ethics approval reference number is: SPPH-LLGB-17-3.2(2022-R013).Written informed consent was obtained from all individual participants included in the Houpe Paiqi mixture study.

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Not applicable.

Competing interests

The authors declare no competing interests.

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Wang, Zz., Liu, Zk., Ma, Wx. et al. Prediction of the risk of severe small bowel obstruction and effects of Houpu Paiqi mixture in patients undergoing surgery for small bowel obstruction. BMC Surg 24, 63 (2024). https://0-doi-org.brum.beds.ac.uk/10.1186/s12893-024-02343-0

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  • DOI: https://0-doi-org.brum.beds.ac.uk/10.1186/s12893-024-02343-0

Keywords

BMC Surgery

ISSN: 1471-2482

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